By October 2020, SARS-CoV-2 has already caused the death of 1 421 650 persons worldwide according to the World Health Organization.
Once more, BD works on advancing the world of health by implementing CerTest VIASURE SARS-CoV-2, the first Real Time PCR Detection KIT.
Table of Contents
COVID-19 Molecular Diagnostics
How does it work?
RT-PCR Molecular tests look for the coronavirus RNA in the airways of people who may carry the virus. Hence, the purpose of these tests is to find people carrying the virus among one of the following two categories:
• Patients to be isolated or patients to be cured depending on the degree of involvement
• Asymptomatic virus carriers who might still be contagious and who must be locked down to avoid the spread of the virus.
BD Max: an efficient way to detect SARS-CoV-2
With over 24 million confirmed cases of COVID-19 in only 9 months, there has been a strong urge to find an efficient method to detect the virus. Hence, BD Max helps labs and clinicians work on better management of the pandemic by allowing an exceptionally accurate detection of COVID-19. Indeed, by testing a larger part of the world’s population, BD Max leads to a better isolation of the infected patients which, in turn, lowers the spread of SARS-CoV-2.
How does it work?
In order to test people suspected of COVID-19, BD MAX System uses BD SARS-CoV-2 Reagents that detect SARS-CoV-2 in nasal, nasopharyngeal and oropharyngeal swabs samples.
Such method relies on multiplexed primers and probes that target RNA from the nucleocapsid phosphoprotein gene (N1 and N2 regions) of the SARS-CoV-2 coronavirus, as well as the human RNase P gene.
How does BD SARS-CoV-2 improve COVID-19 testing?
BD SARS-CoV-2 builds on four key points that have been proven to improve clinical productivity :
1. A simple and automated work-flow for a faster diagnosis.
2. For saving a significant amount of time, BD SARS-CoV-2 offers the possibility to have pre-loaded reagent strips
3. The ability to use 24 samples simultaneously
4. Results are available within 2 hours, which allows a better prevention against the spread of the virus among the population.
CerTest VIASURE SARS-CoV-2 Real Time PCR Detection KIT
By creating the first Real Time PCR Detection KIT, CerTest VIASURE SARS-CoV-2, BD offers an accurate identification of SARS-CoV-2 in respiratory samples from patients suspected of COVID-19. The CerTest VIASURE PCR Detection KIT relies on the extraction and the amplification of RNA using RT-PCR. For a better detection of RNA, fluorescent reporter dye probes are used. In order to offer a more accurate and secure diagnosis, CerTest VIASURE PCR Detection KIT holds all the needed components for RT-PCR assay in addition to an internal control that helps oversee PCR inhibition.
In addition, a tube that snaps into the test-specific position on the BD MAX™ ExK™ TNA extraction strip carries the lyophilized test. CerTest VIASURE SARS-CoV-2 is 100% integrated on the BD MAX™ System. Today more than ever, BD helps you reach clinical efficiency by offering you the latest technology.
References
European Centre for Disease Prevention and Control. “Regional situation assessment – Seasonal influenza, 2019–2020”. 2019. Accessed March 2020.
ReSiVNET. Respiratory syncytial virus. 2019. Available at: http://www.resvinet.org/about-rsv.html. Accessed March 2020.Rangberg A et al. Sci Rep. 2019;9:11917.
European Centre for Disease Prevention and Control. Surveillance of antimicrobial resistance in Europe – Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) 2017. Stockholm: ECDC; 2018. 5.VIASURE SARS-CoV-2 S gene Real Time PCR Detection Kit IFU.
European Data Portal. Widespread Testing: Differing Strategies across Europe. Accessed September 2, 2020. Available from: https://www.europeandataportal.eu/en/impact-studies/covid-19/widespread-testing-differing-strategies-across-Europe.
World Health Organization. WHO coronavirus disease (COVID-19) dashboard. Cumulative data of global confirmed cases. World Health Organization website. Accessed August 28, 2020. Available from: https://covid19.who.int.
Grassly NC et al. Lancet Infect Dis. 2020. doi: 10.1016/S1473-3099(20)30630-7. Online ahead of print. BD SARS-CoV-2 Reagents for BD MAX™ System IFU, P0255(03). Updated August 2020.
Glossary
PCR, polymerase chain reaction;
RT-PCR, real time polymerase chain reaction;
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
DNA, deoxyribonucleic acid;
EEA, European Economic Area;
EU, European Union;
RSV, Respiratory Syncytial Virus;
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2;
TNA, total nucleic acid;
VanR, Vancomycin resistance;
VRE, Vancomycin-resistant enterococci.
